Indomethacin Prior to Difficult Embryo Transfer is it a Solution?
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Implantation rate
研究概览
简要总结
IVF/ICSI patients who had difficult mock embryo transfer on the day of ovum pick up. Will be randomly assigned into two groups; group A will receive 100mg indomethacin rectal suppository 1-2 hours before ET and group B will not receive indomethacin
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Infertile patients undergoing IVF cycle with difficult mock embryo transfer
- •Early follicular FSH level ≤10 IU/L.
- •Tubal, male infertility and unexplained causes of fertility will be recruited.
- •Fresh ET.
排除标准
- •Repeated IVF failure.
- •Past history of allergy to NSAID, bronchial asthma , peptic ulcer or inflammatory bowel disease.
- •Easy mock embryo transfer.
研究组 & 干预措施
Group A (Indomethacin)
All patient had long stimulation protocol and IVF/ICSI. After mock embryo transfer women with any degree of difficulty will receive Indomethacin 100Mg Suppository 1-2 hours before embryo transfer.
干预措施: Indomethacin 100Mg Suppository (Drug)
Group A (Indomethacin)
All patient had long stimulation protocol and IVF/ICSI. After mock embryo transfer women with any degree of difficulty will receive Indomethacin 100Mg Suppository 1-2 hours before embryo transfer.
干预措施: IVF/ICSI (Procedure)
Group B (Control)
All patient had long stimulation protocol and IVF/ICSI. After mock embryo transfer women with any degree of difficulty will not receive any medications before embryo transfer.
干预措施: IVF/ICSI (Procedure)
结局指标
主要结局
Implantation rate
时间窗: 6 weeks
the number of total gestational sacs divided by the total number of embryos transferred.
次要结局
- Ongoing pregnancy rate(12 weeks)
- Clinical pregnancy rate(6 weeks)
研究者
Yasmin Ahmed Bassiouny
Assistant Professor of Obstetrics and Gynaecology
Cairo University