Oxygenation in Vascular Lesions of the Colon
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Quantitative analysis of colonic oxygen saturation levels
研究概览
简要总结
The goal of this clinical trial is to evaluate oxygenation in the colon in people with acquired vascular abnormalities in the proximal colon.
详细描述
The etiology of acquired vascular abnormalities of the large bowel (i.e. angiodysplasia, AVM, hemangiomas of the cecum. etc.) are unknown. These lesions typical appear as ectatic, dilated, and tortuous blood vessels within the submucosa and mucosa of the GI tract. In some patients they are the cause of acute large volume bleeding or a slower chronic bleed that manifests as chronic iron deficiency anemia. These lesions are more common in older individuals and those with underlying cardiac, pulmonary, and renal disease. As such, it is hypothesized that these lesions may result from chronic hypoxia. This study aims to evaluate oxygenation of the colon in people with acquired vascular abnormalities in the proximal colon compared to healthy controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Undergo standard of care colonoscopy
- •People with a history of vascular lesions of the colon
- •People with healthy colon
- •18 - 89 years of age
排除标准
- •Age < 18 years
- •Age > 90 years
- •People with ulcerations in at ascending colon opposite the ileocecal valve
- •Previous colon surgery
研究组 & 干预措施
Vascular abnormality group
People with acquired vascular abnormalities in the proximal colon
干预措施: Oxygen saturation (Other)
Control group
People with healthy colon
干预措施: Oxygen saturation (Other)
结局指标
主要结局
Quantitative analysis of colonic oxygen saturation levels
时间窗: baseline-12 months
Colonic oxygen saturation levels will be compared between patients with vascular lesions of the colon and healthy controls.
次要结局
未报告次要终点