Non-invasive Cardiac Output Monitoring in Patients With Burn Injuries
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Rate of pressor use
研究概览
简要总结
The purpose of this study is to describe the use of non-invasive cardiac output monitors (NICOM) in patients with burn injuries and to develop a protocol for NICOM in a burn unit.
详细描述
Appropriate fluid resuscitation in the first 24 hours after a burn injury directly influences patient outcome and morbidity. Currently, there is some controversy surrounding the over and under-resuscitation and endpoints of resuscitation using older fluid resuscitation formulas in patients with burn injury. The NICOM has been used in the resuscitation of patients with sepsis. The NICOM will be used in patients with burn injury to determine the patient's fluid responsiveness and the need for additional fluid boluses versus medications to increase the patient's blood pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Burn greater than 20% TBSA (total body surface area)
排除标准
- •Burn less than 20% TBSA (total body surface area)
研究组 & 干预措施
NICOM
Subjects with burns greater than 20% total body surface area (TBSA) will have a NICOM placed on them after the first 24 hours of admission if subject has an episode of hypotension (mean arterial pressure < 65 or a systolic blood pressure < 90mmHg). The NICOM will generate a number that reflects stroke volume of the heart. If the number is greater than 10 percent, subject will be given a bolus of crystalloid fluids. If the number is less than 10 percent, subject will start a medication to raise the blood pressure.
Physicians may also use traditional endpoints of resuscitation include base deficit values and urine output goals of 0.5cc/kg/hr as indications of adequate intravenous fluid resuscitation.
干预措施: NICOM (non-invasive cardiac output monitor) (Device)
Control
This is a retrospective comparison control group of patients with burns greater than 20% total body surface area (TBSA) admitted to the hospital from 7/1/2014-12/31/2014.
结局指标
主要结局
Rate of pressor use
时间窗: Duration of hospital stay, an expected average of 30 days
Defined as number of subjects that required pressor support (administration of cardiovascular supportive agents)
Total volume of fluid given
时间窗: 24 hours
The total volume of fluid given to the subjects in the first 24 hours
次要结局
- Rate of pulmonary edema(Duration of hospital stay, an expected average of 30 days)
- Rate of acute renal failure(Duration of hospital stay, an expected average of 30 days)
- Length of stay in intensive care unit (ICU)(3 months)
- Length of hospital stay(3 months)
研究者
Rachael Williams
Associate
Emory University