Diastolic Blood Pressure and Lipid Profile in Breastfed Vs. Formula Fed Infants ( As Early Indicators for Cardiovascular Disease ).
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 主要终点
- Diastolic blood pressure
研究概览
简要总结
The influence of early environmental factors, including nutrition, on future cardiovascular disease (CVD) risk and, in a broader view, the concept of early metabolic programming and future health have been extensively discussed during the past decades. Observational studies have suggested that formula-fed infants as compared with breastfed infants have an elevated risk of future CVD.
详细描述
The influence of early environmental factors, including nutrition, on future cardiovascular disease (CVD) risk and, in a broader view, the concept of early metabolic programming and future health have been extensively discussed during the past decades. Observational studies have suggested that formula-fed infants as compared with breastfed infants have an elevated risk of future CVD, since they have faster early growth rate and higher risk of overweight, type 2 diabetes, high blood pressure, and unfavorable blood lipid profile in adult age. Formula-fed preterm infants have higher serum C-reactive protein (CRP) concentration, higher serum low-density lipoprotein to high-density lipoprotein (LDL:HDL) ratio, and higher serum apolipoprotein B to apolipoprotein A1 (apoB:apoA1) ratio in adolescence as compared with preterm infants receiving banked breast milk.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 10 Months 至 14 Months(Child)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Breastfed infants
- •Formula-fed infants
- •Raw milk fed infants
- •Mixed fed infants
- •Breast milk plus raw milk
- •Breast milk plus formula
排除标准
- •Children with Cong. Heart Disease, family history of congenital hyperlipidemia and cases which prove hyperlipidemia of high levels (congenital).
结局指标
主要结局
Diastolic blood pressure
时间窗: Around one year
Value of Infants feeding
次要结局
- Serum cholesterol level(Around one year)
研究者
El-Shazly Rabeeh Ahmed
Principal Investigator
Assiut University
