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临床试验/NCT03612427
NCT03612427Unknown不适用

Diastolic Blood Pressure and Lipid Profile in Breastfed Vs. Formula Fed Infants ( As Early Indicators for Cardiovascular Disease ).

Assiut University0 个研究点目标入组 120 人开始时间: 2018年8月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
120
主要终点
Diastolic blood pressure

研究概览

简要总结

The influence of early environmental factors, including nutrition, on future cardiovascular disease (CVD) risk and, in a broader view, the concept of early metabolic programming and future health have been extensively discussed during the past decades. Observational studies have suggested that formula-fed infants as compared with breastfed infants have an elevated risk of future CVD.

详细描述

The influence of early environmental factors, including nutrition, on future cardiovascular disease (CVD) risk and, in a broader view, the concept of early metabolic programming and future health have been extensively discussed during the past decades. Observational studies have suggested that formula-fed infants as compared with breastfed infants have an elevated risk of future CVD, since they have faster early growth rate and higher risk of overweight, type 2 diabetes, high blood pressure, and unfavorable blood lipid profile in adult age. Formula-fed preterm infants have higher serum C-reactive protein (CRP) concentration, higher serum low-density lipoprotein to high-density lipoprotein (LDL:HDL) ratio, and higher serum apolipoprotein B to apolipoprotein A1 (apoB:apoA1) ratio in adolescence as compared with preterm infants receiving banked breast milk.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
10 Months 至 14 Months(Child)
性别
All
接受健康志愿者

入选标准

  • Breastfed infants
  • Formula-fed infants
  • Raw milk fed infants
  • Mixed fed infants
  • Breast milk plus raw milk
  • Breast milk plus formula

排除标准

  • Children with Cong. Heart Disease, family history of congenital hyperlipidemia and cases which prove hyperlipidemia of high levels (congenital).

结局指标

主要结局

Diastolic blood pressure

时间窗: Around one year

Value of Infants feeding

次要结局

  • Serum cholesterol level(Around one year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

El-Shazly Rabeeh Ahmed

Principal Investigator

Assiut University

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