The effect of Kyolic aged garlic extract on gut microbiota, inflammation and cognition in hypertensive adults: a 3-month randomised placebo-controlled trial

A/Prof Dr Karin Ried0 个研究点目标入组 50 人开始时间: 2016年2月12日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•Inclusion criteria
•- Essential hypertension: Mean systolic SBP >=140 mm Hg or diastolic blood pressure >=90 mm Hg to be confirmed under trial conditions at the screening appointment (at screening mean DBP of >=88 / SBP >=135 mm Hg will be included)
•- Either not on blood pressure medication, or on established plan of blood pressure medication (one or more classes) for at least 2 months
•- The patient’s doctor is not planning to change current treatment during the 3 month trial
•- Able to give informed consent

•Exclusion criteria
•- Poor comprehension of written or spoken English
•- Current or previous antibiotic treatment within the last 2 months of study enrolment
•- Currently taking anti-inflammatory agents, glucocorticoids or other immune regulating prescription medication
•- Currently taking probiotics
•- Currently taking garlic supplements
•- History of intestinal surgery, inflammatory bowel disease, celiac disease, lactose intolerance, chronic pancreatitis, or diagnosed malabsorption disorder
•- Planning surgery in the next 3-4 months
•- Unstable other medical conditions or serious illness, at the discretion of the GP, e.g. dementia, terminal illness, recent bereavement, secondary hypertension, recent significant medical diagnosis, and pregnancy
•- Severe hypertension (mean sitting SBP>=180 mm Hg and DBP >=110 mm Hg) at enrolment or subsequent visits during the study. Patients with severe hypertension will be referred back to their doctor for further management

发起方

A/Prof Dr Karin Ried