(Effect of Blood Flow Restriction Training on Muscle Strength and Gait Performance in Multiple Sclerosis Patients).
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- muscle strength
研究概览
简要总结
Traditional physical therapy resisted training for people with MS have been shown to be beneficial; however, their usefulness has been limited by fatigue. The effect of blood flow restriction on strength and other measures of physical function was demonstrated in healthy populations and those with chronic disease. This study may add missing information to the existing literature and suggests directions for research on the effectiveness of BFR training on individuals with relapsing and remitting MS.
详细描述
Multiple sclerosis patients are characterized by impaired functional capacity which is related to reduce muscle strength affecting predominantly the lower extremity.
Resistance training (RT) has proven to be one of the interventions in MS patients showing a consistent and positive effect on muscle strength and on parameters directly related to lower extremity physical function (eg, walking performance and stair negotiation).
Training with blood flow restriction (BFR), is an increasingly common clinical intervention among physical therapists over the past decade and consistent with the evidence. It has been investigated in people with neurological disorders including stroke and incomplete Spinal Cord Injuries. Research is limited on the use of BFR for individuals with MS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients were diagnosed with MS by a neurologist according to McDonald's criteria 2010
- •Expanded Disability Status Scale (EDSS) scores ranging from 2.5 to 5.5 .
- •Patient able to walk 100 meters or more.
- •No change within MS specific medication three months from the study.
- •Last Ms Attack from more than two months.
排除标准
- •Multiple sclerosis patients with other neurological or orthopedic problems.
- •Multiple sclerosis patients with systemic problems (cardiovascular or pulmonary diseases...).
- •Patients with cognitive impairment.
- •Pregnant female patients.
- •Patients in acute relapse stage.
结局指标
主要结局
muscle strength
时间窗: one week after the end of treatment
measure maximal torque production at a specified velocity of limb movement. measure torque of hip flexors , extensors , knee flexors and extensors
次要结局
- gait performance by Two-dimensional (2D) Motion Analysis system(one week after the end of treatment)
研究者
Habiba Zienhom Soubhy Mohamed
Principal Investigator
Cairo University