Prognostic value of IL-6 in SIRS- A Prospective observational study

This is a single centre prospective observational study regarding prognostic value of Interleukin-6 among patients with systemic inflammatory response syndrome presenting to ICU of a tertiary care centre.

IL-6 is considered to play an important role as an early indicator of inflammatory response. It is expected that monitoring of such inflammatory parameters would allow to identify the acute moment of the disease and chances of further clinical worsening.

In our study, all study patients will undergo standard treatment according to the discretion of treating physician and study related data will be collected in case record form. Close monitoring of clinical course along with laboratory parameters including biomarkers( Interleukin -6, Procalcitonin, C- reactive protein) will be done till date of discharge from ICU. Detailed analysis will be performed regarding biomarker values with 28 day mortality along with comparison of IL6 value with incidence or onset of organ dysfunction, need for mechanical ventilation and its duration, need for renal replacement therapy with or without cytokine filter, need for vasoactive agents or ECMO, duration of ICU stay.

With increasing mortality rates in patients with hyper inflammatory states including septic shock, if role of IL-6 in prognostication can be shown it could pave path for early therapy targeted at reducing inflammatory markers which could in turn help in reducing morbidity as well as mortality.