Observational, Multicenter, Cross-sectional Study at National Level to Analyze the Histopathological, Ultrastructural and Microbiological Findings Obtained in Autopsies of Patients Who Died Due to COVID-19 in Spain
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 10
- 主要终点
- Histopathological and ultra-structural findings
研究概览
简要总结
The aim of this study is prospectively analyzing the histopathological, ultrastructural and microbiological findings from autopsies performed on patients with COVID-19.
详细描述
The aim of this study is to increase the knowledge of the pathogenic mechanisms of the COVID-19 disease, that will allow us to improve the design of clinical and therapeutic strategies against the disease. This is the tool to improve the prognosis of patients with COVID-19.
The performance of systematic and regulated autopsies can help to manage it. However, despite the need to generate this knowledge and the strong impact on mortality caused by the COVID-19 pandemic, the evidence from post-mortem studies is very limited.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with COVID-19 infection confirmed by PCR.
- •Death related to active infection by COVID-19 or its complications.
- •Informed consent given by the subject's relatives to perform an autopsy according to the autonomous community requirements.
- •Informed consent given by the subject's relatives for the inclusion of samples in the Biobank.
排除标准
- •COVID-19 infection diagnosed exclusively by serological methods.
- •Advanced or terminal chronic disease.
- •Inadequate security level of the autopsy room.
结局指标
主要结局
Histopathological and ultra-structural findings
时间窗: End of autopsy
To analyze the histopathological and ultra-structural findings obtained in complete and systematic autopsies of patients who died due to COVID-19.
次要结局
- Histopathological / ultra-structural findings and clinical / biological expression correlation(End of autopsy)
- Molecular characterization(End of autopsy)
- Hidden pulmonary superinfections(End of autopsy)