The Diagnostic Assessment and Intervention Study of Amphetamine Type Stimulus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 560
- 试验地点
- 1
- 主要终点
- the prevalence of ATS abuse or dependence characteristics and pathogenesis
研究概览
简要总结
The purpose of this research is to inspire new medical ideas using brain image technology for the treatment of Amphetamine Type Stimulus addition, at the same time lowing the addition damage.
详细描述
The study will increase the sample size based on the preliminary work,also, establish drug dependence induced craving associated environmental experiments , by using the multi-lead biofeedback instrument , CogState tester, event-related potentials Recorder and 3.0T high-field magnetic resonance imaging system to record the physiology , electrophysiology and brain changes during craving, taking a subjective self-assessment , clinical observations and physiological responses combined system to evaluate the ATS addiction degree.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •No previous history of any mental disorder meet the DSM-IV diagnosis
- •aged 18-49 years old , men and women
- •junior high school or higher education
- •use of amphetamine-type substances time for more than one year
- •cumulative use of amphetamines, substances dose of 50 grams or more.
排除标准
- •Current or past had suffered neurological diseases
- •exclusion of antisocial personality disorder and borderline personality disorder
- •addicts in addition to other substances in tobacco , coffee, social drinking outside
- •AIDS virus (HIV) detection positive patients .
结局指标
主要结局
the prevalence of ATS abuse or dependence characteristics and pathogenesis
时间窗: Baseline
Plasma and DNA samples were collected to carry out the biochemical genetics and immunology research of ATS abuse or dependence , and to explore the prevalence of ATS abuse or dependence characteristics and pathogenesis.
the physiological psychology and cognitive impairment characteristic of ATS addicts,trends and ATS conducted cases.
时间窗: Baseline
Use repeatable battery for the assessment of neuropsychological status(RBANS),Cog-state cognitive function assessment test,event-related potentials(ERPs),functional magnetic resonance imaging(fMRI) in biology ( molecular genetics, blood biochemistry, electrophysiology , imaging ) , psychology, mental health and other aspects of the system to assess the physiological psychology and cognitive impairment characteristic of ATS addicts , trends and ATS conducted cases.
次要结局
未报告次要终点
研究者
Min ZHAO
Vice President
Shanghai Mental Health Center