Predictive Biomarkers of Secondary Aggravation in Covid-19 Suspect Patient Admitted to Emergency Departments During an Epidemic
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 373
- 试验地点
- 1
- 主要终点
- Rate of secondary aggravation
研究概览
简要总结
There is no predictive tool for patients admitted to the emergency department with a suspicion of Covid-19 that will worsen secondarily and require a heavy lifting.
In a context of saturation of the healthcare system by the pandemic at Covid-19,it is essential to identify specific, accessible prognostic markers via minimally invasive sampling with low risk of infection for personnel caregiver, for optimal allocation of resuscitation resources.
This study proposes to evaluate the biological markers of routine care known to be associated with resuscitation admission in relation to hospitalization on conventional service for the prediction of worsening of patients admitted to the emergencies for Covid-19.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical criteria for suspicion of Covid-19 in an epidemic period
- •Consultation in the emergency departement
- •Non-opposition agree
排除标准
- •impairment related to another identified cause than Covid-19, in particular a rapid diagnostic test flu-positive
- •Severe patient from the outset with transfer to intensive care within 12 hours of admission to the Emergency Department
- •No social security coverage (beneficiary or entitled person)
- •Poor understanding of French
- •Refusal to participate
结局指标
主要结局
Rate of secondary aggravation
时间窗: an average at 30 days (- 2 days +3 days) of admission to the emergency department
Secondary aggravation is defined as : * a re-hospitalization or * aggravation in hospitalization : development or increase in oxygen dependency, hemodynamic failure, and/or respiratory, death
次要结局
- Change of standart biological parameters(Between baseline and an average at 30 days (- 2 days +3 days) of admission to the emergency department)
- Change of Von willebrand factor (vWF) changes over time(Between baseline and an average at 30 days (- 2 days +3 days) of admission to the emergency department)
- Change of the Factor VIII (FVIII)(Between baseline and an average at 30 days (- 2 days +3 days) of admission to the emergency department)
- Prevalence of positivity of COVID-19 virus measured by PCR or serology(an average at 30 days (- 2 days +3 days) of admission to the emergency department)