NCT03629561Unknown不适用
Diagnosis of Monoclonal Gammopathy of Renal Significance in Patients With Paraproteinemias
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Renal histopathology compatible with MGRS
研究概览
简要总结
This is the first prospective study which evaluate patients with small B-cell clones to diagnose monoclonal gammopathy of renal significance (MGRS) and characterize it clinically, anatomopathologically and pathophysiologically taking int account a geriatric approach.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Paraproteinemias
排除标准
- •Multiple Myeloma
- •Waldenstrom Macroglobulinemia
- •Chronic Lymphocytic Leukemia
- •Malignant Lymphoma
- •Monoclonal gammopathy of unknown significance (MGUS) secondary to Infections
- •MGUS secondary to Autoimmune Diseases
- •Uncompleted hematological evaluation
- •Renal tumor except for cysts Bosniak type I/II
- •Other malignant neoplasia
- •Unresolved obstructive uropathy
- •Patients with only one kidney except for renal transplant
- •Co-morbidities which would limit the ability to receive aggressive therapeutic intervention
- •Fragile old people
- •Pregnancy
- •Impatient in psychiatric institutions.
结局指标
主要结局
Renal histopathology compatible with MGRS
时间窗: through study completion, an average of 1 year
次要结局
- Renal physiopathological changes(through study completion, an average of 1 year)
研究者
MARIANA CIOCCHINI
Principal Investigator
Academia Nacional de Medicina
研究点 (1)
Loading locations...
相似试验
已完成
2 期
Imaging in MGUS, SMM and MMMonoclonal Gammopathy of Undetermined SignificanceSmoldering Multiple MyelomaMultiple MyelomaNCT01237054National Cancer Institute (NCI)31
进行中（未招募）
1 期
Monoclonal gammopathies of renal significance (MGRS) in FinlandRare renal diseases linked to monoclonal gammopathyMedDRA version: 20.0Level: SOCClassification code 10038359Term: Renal and urinary disordersSystem Organ Class: 10038359 - Renal and urinary disordersEUCTR2021-005856-12-FIHelsinki University Central Hospital35
已完成
1 期
Pilot Study of Rituximab for Membranoproliferative GlomerulonephritisGlomerulonephritis, MembranoproliferativeNCT00275613Mayo Clinic10
已完成
不适用
MGRS: Clinical-histological Features of a Multicenter Case SeriesMonoclonal Gammopathy of Renal SignificanceNCT05119309University of Milano Bicocca87
Unknown
不适用
Utility of Urinary beta2 Microglobulin as an Early Marker of Renal Dysfunction in Vietnamese HIV-Infected PatientsHIV InfectionRenal Function DisorderRenal Tubular DisorderNCT02256579National Center for Global Health and Medicine, Japan1,800