Understanding Hallucinations (Part I) - Phenomenology and Cognition
试验速览
- 阶段
- 不适用
- 发起方
- UMC Utrecht
- 入组人数
- 700
- 试验地点
- 4
- 主要终点
- The number of clusters of patients with shared symptom profiles as determined by latent class analysis, and the difference in scores on cognitive assessment between these identified clusters.
研究概览
简要总结
Psychotic symptoms (hallucinations and delusions) are present in several psychiatric and neurological disorders as well as in the general population. Effective treatment strategies for these symptoms in all patients are lacking and treatment-response can presently not be predicted. To date, the exact pathophysiological mechanism of these symptoms remains unknown. By investigating (subtypes) of hallucinations and delusions in all populations, a common pathway may be found, leading to more effective treatment options. Alternatively, different subtypes may be associated with different pathophysiological mechanisms.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age > 18 years
- •mentally competent
- •in case of delirium: family member able to give informed consent
- •Individuals with hallucinations will have to experience at least one episode of hallucinations over the last month.
- •Individuals without hallucinations: no current hallucinations and a history of maximum 1 episode of hallucinations with a maximum duration of 1 week, at least two years ago.
排除标准
- •Age <18)
- •Participants that cannot read, speak or understand Dutch
- •For all included diagnostic groups except delirium: Mentally incompetent individuals who are not capable to provide informed consent, as determined by their treating physician.
结局指标
主要结局
The number of clusters of patients with shared symptom profiles as determined by latent class analysis, and the difference in scores on cognitive assessment between these identified clusters.
时间窗: Three years
次要结局
- The internal consistency, test-retest reliability, inter-rater reliability, criterion validity and construct validity of a newly developed questionnaire.(Two years)
- The difference in scores on cognitive assessment between participant groups with and without psychotic symptoms.(Three years)