The Effects of an Active Older Adult Program at the Dan Abraham Healthy Living Center on Health and Well-being
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Change in repeated chair rise time
研究概览
简要总结
The purpose of this study is to determine whether a structured 12-week program designed for older adults will improve physical function and, in parallel, circulating biomarkers of aging
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women age 55 years or older.
- •Membership at the DAHLC.
- •New to AOA (Active Older Adult) Program and commitment to full participation in the twelve-week program.
- •Must be able to get down and off the floor with little assistance.
排除标准
- •Inability to provide informed consent.
- •Previous participation in the AOA Program at the DAHLC.
结局指标
主要结局
Change in repeated chair rise time
时间窗: Baseline to end of study, approximately 14 weeks
Chair stand test where participants will perform a chair rise movement for five repetitions. The series of 5 repetitions will be timed and measured in seconds.
Change in plasma protein levels reflective of biological age
时间窗: Baseline, week 12
Blood samples will be obtained at baseline and at 12 weeks. The concentration of target proteins (pg/mL) in the plasma will be measured and compared between baseline and week 12.
Change in expression of senescence-related genes in blood cells
时间窗: Baseline, week 12
Blood samples will be obtained at baseline and at 12 weeks. The expression of senescence-related genes (arbitrary units) will be measured in immune cells isolated from whole blood and compared between baseline and week 12.
次要结局
- Change in Self-reported Physical Function(Baseline, week 12)
- Change in Performance-based Physical Function(Baseline, week 12)
- Change in Mental Function(Baseline, week 12)
- Change in self-assessment of well-being(Baseline, week 12)
研究者
Nathan K. LeBrasseur
Principal Investigator
Mayo Clinic