Effects of Mixed Nut Consumption on Satiety and Weight Management
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- Change of Satiety
研究概览
简要总结
The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management. While numerous studies have shown the beneficial effects of nuts on promoting negative energy balance and weight loss, mechanistic studies exploring how the inclusion of nuts in the diet promotes a negative energy balance and weight loss have not been conducted. The second goal is to determine the mechanisms by which mixed nut consumption regulates of food intake and body weight.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-55 years old
- •BMI 27-40
排除标准
- •Pregnant woman
- •Required dietary supplement use
- •Required medication of metabolic disorders
- •Allergy to nuts or gluten
结局指标
主要结局
Change of Satiety
时间窗: 0, 20, 40, 60, 90 and 120 minutes post snack consumption
Hunger feeling (appetite) will be examined using visual analog scale (0-10): 0 least and 10 greatest
Change of insulin level
时间窗: Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption
Insulin level will be examined using an ELISA biochemical method
Change of glucose level
时间窗: Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption
Glucose level will be examined using glucose analysis
Change of cholesterol levels
时间窗: 8 weeks and 16 weeks post daily consumption
Cholesterol levels will be examined using a biochemical method
Change of Lp(a)
时间窗: 8 weeks and 16 weeks post daily consumption
Lp(a) levels will be examined using an ELISA biochemical method
次要结局
- Change of microbiome(8 weeks and 16 weeks post daily consumption)