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临床试验/NCT01071629
NCT01071629Unknown不适用

Aerobic Interval Training Versus Combined Aerobic Interval Training and Strength Training Effects in Patients With Heart Failure

University of Athens2 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2004年11月1日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
40
试验地点
2
主要终点
Aerobic exercise capacity

研究概览

简要总结

Chronic heart failure (CHF) is a common syndrome characterized by several central hemodynamic and peripheral vascular and muscle abnormalities including autonomic imbalance, neuro-hormonal over-activation and decreased oxidative status.

In patients suffering from CHF, exercise confers several beneficial effects on the cardiovascular and peripheral systems, mainly by continuous aerobic training. However, interval aerobic training has also been validated as an alternate form of training that increases the exercise capacity of patients who are in CHF.

Recent studies have suggested that resistance training alone or as a complementary program besides the traditionally aerobic continuous training might exert favorable effects. However, little it is known about the combined effects of interval and strength training in CHF patients.

Aim of this prospective randomized controlled study was to investigate the effects of combined interval and strength training comparing to interval training alone in CHF patients.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Stable systolic heart failure
  • NYHA functional class ≤ III
  • Optimal medical treatment

排除标准

  • Contraindications for a maximal cardiopulmonary exercise testing (CPET) according to the American Thoracic Society/American College of Chest Physicians Statement
  • Moderate to severe COPD

结局指标

主要结局

Aerobic exercise capacity

时间窗: 3 months

次要结局

  • Endothelial function, oxygen kinetics, ventilatory drive(3 months)

研究者

发起方
University of Athens
申办方类型
Other
责任方
Principal Investigator
主要研究者

Serafim Nanas

MD

University of Athens

研究点 (2)

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