Effects of switching from sacubitril/valsartan to valsartan alone on plasma levels of natriuretic peptides and cardiac remodeling in heart failure with reduced ejection fraction - SAVASAVA Study

The %Change in ANP and NT-proBNP levels was significantly greater in the ARB-switch group than that in the ARNI-continue group, wheras that in BNP levels was not significantly different between the ARNI-continue and ARB-switch group. In the ARB-switch group, there was a significant increase from the baseline to week 24 in left ventricular (LV) end-systolic volume (p = 0.043) and LV peak-systolic wall stress (p = 0.012), and a trend toward a decrease in LV ejection fraction (p = 0.080).