A Pilot Study to Correlate DNA Sequence Copy Number Abnormalities With Outcome in Patients With Advanced Epithelial Ovarian Cancer
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Association between above chromosomal changes and clinical characteristics
研究概览
简要总结
This research trial studies tissue samples from patients with ovarian cancer in the laboratory. Analyzing tissue samples from patients in the laboratory may help doctors learn more about cancer.
详细描述
OBJECTIVES:
I. Utilize array comparative genomic hybridization and Taqman analyses, a quantitative genomic polymerase chain reaction, to validate the observation that a gain in chromosome 8q is predictive of shorter progression-free survival in patients with primary grade 2 or grade 3 advanced serous papillary ovarian cancer.
II. Utilize these analyses to determine whether a gain in chromosome 8q is predictive of worse overall survival in these patients.
III. Utilize these analyses to determine whether other previously identified chromosomal changes (3q gain, 7q gain, 16q loss, and 17pter-q21 loss) predict outcome in these patients and the association between these changes and clinical characteristics.
IV. Utilize these analyses to identify up to 5 additional chromosomal changes and their association that may predict outcome (progression-free and overall survival) in these patients.
研究设计
- 研究类型
- Observational
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Stage III or IV, high-grade (grade 2 or 3) ovarian cancers
- •No borderline or low-grade (grade 1) tumors
- •Tissue from predominately serous ovarian cancer only
- •No clear cell, endometrioid, mucinous, transitional cell, or mixed without predominant serous component
- •Tissue obtained during prior optimal or suboptimal cytoreductive surgery
- •Must be enrolled on GOG-0136 and a GOG front-line paclitaxel/platinum chemotherapy trial
- •Frozen tissue and hematoxylin-eosin stained section from the ovary obtained at initial surgery
- •Performance status - GOG 0-2
排除标准
- 未提供
结局指标
主要结局
Association between above chromosomal changes and clinical characteristics
时间窗: baseline
Determination of whether other previously identified chromosomal changes (3q gain, 7q gain, 16q loss, and 17pter-q21 loss) predict outcome
时间窗: baseline
Identification of up to 5 additional chromosomal changes and their association that may predict outcome (progression-free and overall survival)
时间窗: baseline
Validation of the observation that a gain in chromosome 8q is predictive of shorter progression-free survival in patients with primary grade 2 or grade 3 advanced serous papillary ovarian cancer by PCR and Taqman analyses
时间窗: baseline
Determination of whether a gain in chromosome 8q is predictive of worse overall survival in these patients
时间窗: baseline
次要结局
未报告次要终点