The role of bile acids in human brown adipose tissue metabolism - Brown adipose tissue activity and bile acids

niversiteit Maastricht0 个研究点目标入组 18 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•- Caucasians
•- Age: 18-30 years
•- Gender: male and female (females only on a specific oral contraceptive pill; microgynon 30 or levonorgestrel/ethinylestradiol)
•- BMI: 18-25 kg/m2
•- Good general health

•- Psychologically unstable subjects (as judged by the treating medical specialist)
•- Subjects with mental retardation (as judged by the treating medical specialist)
•- Subjects with severe behavior disorders (as judged by the treating medical specialist)
•- Pregnancy or lactation
•- The use of the following medication one month before the study is an exclusion criterium; ß-blockers, ursodeoxycholic acid, bile acid sequestrants and antacida
•- Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
•- Abuse of drugs and/or alcohol
•- Severe diabetes which requires application of insulin or patients with diabetes-related complications
•- Surgery of the gastro-intestinal tract (only appendectomy is allowed)
•- Previous ERCP with papillotomy
•- History of cholesystectomy or disease of the gallbladder, biliary system and/or liver
•- Hyperthyroidism or hypothyroidism
•- BMI > 25 kg/m2
•- Participation in earlier research or medical examinations that included PET/CT scanning

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