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临床试验/NCT01326507
NCT01326507已完成不适用

Performances de l'h-FABP Pour Identifier dès Les Urgences Les Embolies Pulmonaires d'évolution défavorable

University Hospital, Toulouse2 个研究点 分布在 1 个国家目标入组 165 人开始时间: 2009年9月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
165
试验地点
2
主要终点
number of death by pulmonary embolism

研究概览

简要总结

The patients presenting with acute pulmonary embolism and right ventricular dysfunction are at high risk for life-threatening events and must be identified in the emergency department for adequate care and hospital admission. Echocardiography can identify right ventricular dysfunction, but this test is not always available, and echocardiographic criteria of right ventricular dysfunction vary among published studies. The primary purpose of this protocol is to study the prognostic value of a cardiac biomarker, h-FABP (heart-type Fatty Acid-Binding Protein) , to identify in the emergency department the patients presenting with high risk pulmonary embolism. As secondary outcomes, H-FABP results will be compared to other cardiac biomarkers (BNP, troponin) and clinical score performances that have been previously studied to stratify the prognosis of patients with pulmonary embolism in the emergency department.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patients with acute pulmonary embolism diagnosed in the emergency departement

排除标准

  • patient under guardianship
  • patient without social insurance
  • pregnant women
  • refusal to sign the consent
  • myocardial infarction in the 10 days before pulmonary embolism

结局指标

主要结局

number of death by pulmonary embolism

时间窗: 1 month

life-threatening pulmonary embolism (cardiopulmonary arrest, shock, mechanical ventilation)

时间窗: 1 month

recurrent episode of pulmonary embolism

时间窗: 1 month

次要结局

  • prognostic value of a clinical score (PESI), BNP and troponin in acute pulmonary embolism(1 month)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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