NCT01533545终止不适用
Effect of Epinephrine on Systemic Absorption of Mepivacaine Administered for Brachial Plexus Block in Patients With Chronic Renal Insufficiency
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Plasma concentration of mepivacaine
研究概览
简要总结
The aim of this study is to determine the effect of epinephrine on systemic absorption of local anaesthetic mepivacaine administered for brachial plexus block in uremic patients scheduled for creation or repair of an arteriovenous fistula. Furthermore, an impact of epinephrine on the central circulation and peripheral tissue oxygenation will be evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient acceptance of regional anaesthesia
排除标准
- •peripheral arteriosclerosis
- •diabetes mellitus
- •bleeding disorder
- •infection at the puncture site
- •allergy to mepivacaine
- •pregnancy
研究组 & 干预措施
Plain mepivacaine
Active Comparator
干预措施: Plain mepivacaine (Drug)
Mepivacaine with epinephrine
Active Comparator
干预措施: Mepivacaine with epinephrine (Drug)
结局指标
主要结局
Plasma concentration of mepivacaine
时间窗: 0, 5, 10, 20, 30, 45, 60, 120, and 180 min after blockade
次要结局
- Central circulation(0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, and 60 min after blockade)
- Peripheral tissue oxygenation(0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, and 60 min after blockade)
- Cardiotoxicity of local anesthetic(0, 5, 10, 20, 30, 45, and 60 min after blockade)
- Neurotoxicity of local anesthetic(Continuously for 1 hour after blockade)
研究者
Robertas Martusevicius
Principal Investigator
Rigshospitalet, Denmark
研究点 (1)
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