临床试验/NCT05974852

NCT05974852已完成不适用

Effect of Ocrelizumab on Choroid Plexus Changes in Patients With Primary-progressive Multiple Sclerosis Participating in the ORATORIO: a Post-hoc Analysis of a Double-blind, Randomized, Phase 3, Placebo-controlled Study

State University of New York at Buffalo1 个研究点分布在 1 个国家目标入组 732 人开始时间: 2023年10月1日最近更新: 2026年3月9日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: State University of New York at Buffalo
入组人数: 732
试验地点: 1
主要终点: T2 lesion volume

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The goal of this non-interventional, observational study is to learn if cortical plexus enhancement in patients with primary progressive multiple sclerosis occurs in response to the autoimmune inflammatory process.

详细描述

To study the effect of ocrelizumab on choroid plexus changes in patients with primary-progressive multiple sclerosis participating in the ORATORIO: a post-hoc analysis of a double-blind, randomized, phase 3, placebo-controlled study

研究设计

研究类型: Observational
观察模型: Case Only
时间视角: Retrospective

入排标准

年龄范围: 18 Years 至 65 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Patient participating in the ORATORIO study
•MRI scans available at baseline
•Presence of T2-weighted image (WI) (FLAIR, T2/PD), and 3D T1-WI at baseline

排除标准

未提供

结局指标

主要结局

T2 lesion volume

时间窗: 5 years

T2 lesion volume as measured using MRI.

次要结局

Changes in choroid plexus(5 years)

研究者

发起方

State University of New York at Buffalo

申办方类型

Other

责任方

Principal Investigator

主要研究者

Robert Zivadinov, MD, PhD

Principal Investigator

State University of New York at Buffalo

研究点 (1)

Loading locations...

相似试验

终止

3 期

Study to Evaluate Eye Function in Patients Taking Linezolid for Six Weeks or GreaterOptic Nerve Diseases

NCT00359632Pfizer34

撤回

2 期

OSIG-eye Drops Treatment for Dry Eye DiseaseDry Eye

NCT04510428University of Illinois at Chicago

已完成

不适用

Effect of Intraocular Lens (IOL) Centration and Tilt on Visual Performance With Clareon® Vivity® IOL ImplantationCataractLenses, Intraocular

NCT05827133East Coast Institute for Research101

已完成

4 期

Choroidal Morphology Changes After Aflibercept Therapy in Pachychoroid NeovasculopathyPachychoroid Neovasculopathy

NCT05662410Kim's Eye Hospital30

终止

不适用

Prevention of Photoparoxysmal Abnormalities by Mozart K448Photoparoxysmal AbnormalitiesSeizuresEpilepsy

NCT01363154Medical University of South Carolina10