NL-OMON35030已完成2 期
Safety and efficacy of the addition of simvastatin to cetuximab in k-ras mutant advanced or metastatic colorectal cancer patients. A single-arm, multicenter, phase II study using a Simon two stage design. - RASTAT-C
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 46
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Advanced or metastatic colorectal cancer failing prior 5FU, oxaliplatin and irinotecan
- •- Mutation in codon 12, 13 or 61 of k-ras gene on tumor sample
- •- Adequate condition (WHO 0-2)
- •- Adequate organ function
- •- Written informed consent
- •- Age >= 18 years
- •- Progressive disease in the past 3 months
排除标准
- •- Prior EGFr inhibiting therapy
- •- Symptomatic brain metastasis
- •- Using verapamil or amiodarone
- •- Symptomatic hypothyroidism
- •- History of interstitial lung disease
- •- History of toxicity during statin use
研究者
相似试验
进行中（未招募）
不适用
Safety and efficacy of the addition of simvastatin to panitumumab in k-ras mutant advanced or metastatic colorectal cancer patients.A single-arm, multicenter, phase II study using a Simon two stage design. - RASTAT-PEUCTR2009-014452-30-NLAcademisch ziekenhuis Leiden acting under the name of Leids Universitair Medisch Centrum
进行中（未招募）
不适用
Safety and efficacy of the addition of simvastatin to cetuximab in k-ras mutant advanced or metastatic colorectal cancer patients.A single-arm, multicenter, phase II study using a Simon two stage design. - RASTAT-Ck-ras mutant advanced or metastatic colorectal cancer failing prior 5-FU, oxaliplatin, and irinotecan containing regimens.MedDRA version: 12.1Level: LLTClassification code 10061451Term: Colorectal cancerEUCTR2009-017384-42-NLAcademisch ziekenhuis Leiden acting under the name of Leids Universitair Medisch Centrum
招募中
不适用
Effect if Simvastatin (Drug) in Liver CirrhosisCTRI/2021/12/038917Institute of Liver and Biliary Sciences
招募中
2 期
Protective effect of simvastatin on inflammatory factorIRCT20200421047152N3Iran University of Medical Sciences84
招募中
2 期
Effect of simvastatin in treatment of pachyonychia congenitaIRCT20160320027109N3Shahid Beheshti University of Medical Sciences20