Intestinal Microbiota Changes After Ultra Violet Radiation B Exposure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Microbiome
研究概览
简要总结
This research will explore the potential effects of Narrow-Band Ultra Violet B (NB-UVB) radiation on the intestinal microbiota composition and confirm a regulatory skin-to-gut axis during baseline conditions. Changes in the intestinal microbiota composition caused by NB-UVB phototherapy could be beneficial for patients with chronic/auto-inflammatory diseases like inflammatory bowel disease (IBD) by removing dangerous bacteria, increasing beneficial bacteria, and ultimately modulating immune responses.
详细描述
Purpose:
To explore the potential effects of Narrow-Band Ultra Violet B (NB-UVB) radiation on the intestinal microbiota composition in humans and confirm a regulatory skin-to-gut axis during baseline conditions.
Hypothesis:
Humans exposed to UVB-NB light will show changes in the intestinal microbiota composition with the selection of certain phyla of bacteria.
Justification:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy Caucasian females
- •Fitzpatrick skin type I, II or III
排除标准
- •Skin photosensitivity due to medication
- •Been on vacation to a sunny destination three months before enrollment
- •Visit tanning beds on a regular basis in the past
研究组 & 干预措施
UVB- exposure
Each participant will receive a pre-determined dose of UVB light. Serum Vitamin D and microbiome samples of each participant will be compared before and after the UVB light exposures.
干预措施: NB-UVB light exposure (Radiation)
结局指标
主要结局
Microbiome
时间窗: Before and after the UVB exposures (1 week apart)
Changes in the fecal microbiome composition after the UVB light exposures
Serum vitamin D
时间窗: 1 week
The effect of UVB light exposures on the serum vitamin D concentrations
次要结局
未报告次要终点
研究者
Bruce Vallance
Principle Investigator
University of British Columbia