Intestinal Microbiota Changes After Ultra Violet Radiation B Exposure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Serum vitamin D
研究概览
简要总结
This research will explore the potential effects of Narrow-Band Ultra Violet B (NB-UVB) radiation on the intestinal microbiota composition and confirm a regulatory skin-to-gut axis during baseline conditions. Changes in the intestinal microbiota composition caused by NB-UVB phototherapy could be beneficial for patients with chronic/auto-inflammatory diseases like inflammatory bowel disease (IBD) by removing dangerous bacteria, increasing beneficial bacteria, and ultimately modulating immune responses.
详细描述
Purpose:
To explore the potential effects of Narrow-Band Ultra Violet B (NB-UVB) radiation on the intestinal microbiota composition in humans and confirm a regulatory skin-to-gut axis during baseline conditions.
Hypothesis:
Humans exposed to UVB-NB light will show changes in the intestinal microbiota composition with the selection of certain phyla of bacteria.
Justification:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy Caucasian females
- •Fitzpatrick skin type I, II or III
排除标准
- •Skin photosensitivity due to medication
- •Been on vacation to a sunny destination three months before enrollment
- •Visit tanning beds on a regular basis in the past
研究组 & 干预措施
UVB- exposure
Each participant will receive a pre-determined dose of UVB light. Serum Vitamin D and microbiome samples of each participant will be compared before and after the UVB light exposures.
干预措施: NB-UVB light exposure (Radiation)
结局指标
主要结局
Serum vitamin D
时间窗: 1 week
The effect of UVB light exposures on the serum vitamin D concentrations
Microbiome
时间窗: Before and after the UVB exposures (1 week apart)
Changes in the fecal microbiome composition after the UVB light exposures
次要结局
未报告次要终点
研究者
Bruce Vallance
Principle Investigator
University of British Columbia