Enhanced Diagnostics for Early Detection of Atrial Fibrillation - DETECT AF Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 287
- 试验地点
- 1
- 主要终点
- Beat to beat variation of the electrical activation vector of the atrium
研究概览
简要总结
Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present.
The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display abnormalities in diseased atria which are vulnerable for AF.
详细描述
In the first part of this trial different diagnostic techniques to detect arrythmogenic substrates of atrial fibrillation will be tested. If suitable parameters can be identified, a follow up trial to identify patients at risk for AF will be conducted before a stroke happens.
Parameters tested are
- Electrophysiological differences between patients with paroxysmal AF and no history of AF
- "Vascular Stiffness" detected by an iPhone app
All patients will undergo a cardiogoniometrie and a pulse wave analysis with an iPhone. Each exam takes 5 minutes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •paroxysmal atrial fibrillation in sinus rhythm at presentation
排除标准
- •acute cerebral trauma
- •antiarrhythmic medication
结局指标
主要结局
Beat to beat variation of the electrical activation vector of the atrium
时间窗: Once during the exam (baseline) - No further follow up planned
Test if the beat to beat Variation of the electrical activation of the atrium differentiates between the group of patients with paroxysmal AF and no AF in history.
次要结局
- Heart rate variability(Once during exam (5min, baseline) - No further follow up planned)
- Averaged slope of pressure-curve(Once during exam (5min, baseline) - No further follow up planned)
研究者
Jens Eckstein
MD, PhD
University Hospital, Basel, Switzerland