Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Body temperature
研究概览
简要总结
Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents.
The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 12 Months 至 8 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) Physical Status classification I
- •underwent surgery between 8 to 9 am
- •undergoing ambulatory anesthesia with ketamine
排除标准
- •who required endotracheal intubation
- •who were administered with medications other than ketamine
研究组 & 干预措施
Anticholinergic premedication
Premedication with 0.005mg/Kg of glycopyrrolate
干预措施: Glycopyrrolate (Drug)
结局指标
主要结局
Body temperature
时间窗: every 30 minutes from base line ( up to 90min )
measured body temperature at three times in both ears and the highest value was selected.
次要结局
- Oral secretion (VAS)(up to operative end)
研究者
Won Joo Choe
M.D., Ph.D., Associate professor,
Inje University