NCT00185900已完成不适用
Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 192
- 试验地点
- 1
- 主要终点
- Number of Participants With Prevention of Preterm Delivery for 48 Hours With Attainment of Uterine Quiescence
研究概览
简要总结
To compare intravenous magnesium sulfate to oral nifedipine for acute tocolysis of preterm labor
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •:- Uterine contractions and cervical change or ruptured membranes in a preterm gestation
排除标准
- •placental abruption, fetal distress, placenta previa, maternal medical contraindication to tocolysis
研究组 & 干预措施
Magnesium Sulfate
Active Comparator
Preterm labor treatment with Magnesium Sulfate.
干预措施: Magnesium Sulfate (Drug)
Nifedipine
Active Comparator
Preterm labor treatment with Nifedipine.
干预措施: Nifedipine (Drug)
结局指标
主要结局
Number of Participants With Prevention of Preterm Delivery for 48 Hours With Attainment of Uterine Quiescence
时间窗: 48 hours after administration of study medication.
Uterine quiescence defined by 12 hours of six or fewer contractions per hour and no further cervical change within 48 hours of tocolytic initiation.
次要结局
- Serious Maternal Adverse Effect(From study enrollment until discharge from delivery hospital, up to 30 days after delivery.)
- Gestational Age at Delivery(Until delivery, up to 42 weeks of gestation)
- Time to Uterine Quiescence(Until delivery, up to 42 weeks of gestation)
- Neonatal Birth Weight(Until delivery, up to 42 weeks of gestation)
- Composite Neonatal Morbidity(From delivery until discharge from the hospital, up to 30 days of age)
研究者
Yasser Yehia El-Sayed
Principle Investigator
Stanford University
研究点 (1)
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