NCT00991575已完成不适用
Long Term Vascular Changes in Type 1 Diabetes, Clinical Aspects and Biological Markers
Oslo University Hospital1 个研究点 分布在 1 个国家目标入组 33 人开始时间: 2009年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Fatal and non fatal cardiovascular disease (CVD) and stroke
研究概览
简要总结
The main purpose of this study is to investigate progression of late complications of diabetes during the last ten years in a well characterized cohort of type 1 diabetes with a long duration of the disease, and to define factors responsible for the progression of late complications.
详细描述
Despite intensively research in the field of hyperglycaemia and coronary heart disease in type 1 diabetes it is still not known in detail how hyperglycaemia leads to damage of the vessels.
The aims of the present proposal are therefore two-fold:
- To study in detail the progression of atherosclerosis (and micro vascular complications) in a well characterized cohort of type 1 diabetes with a long duration of the disease. This project will be a continuation of the Oslo study, a cohort started in 1982, with the last follow-up study in 1999/2000.
- To define factors responsible for the progression of coronary heart disease (and micro vascular complications) in this cohort.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-45 years
- •Diagnosis of type 1 diabetes at < 30 years of age, disease duration > 7 but < 30 years
- •C-peptide < 0, 1 nmol/l
排除标准
- •Serum creatinine > 150 µmol/l
- •Diastolic blood pressure <100mmHg
- •Overt nephropathy
- •Proliferative retinopathy
- •Pregnancy
- •A history of neuropathy
- •Other chronical disease
- •Treatment with other drugs except insulin and oral contraceptives
结局指标
主要结局
Fatal and non fatal cardiovascular disease (CVD) and stroke
时间窗: One year
次要结局
- Vessel area stenosis(One year)
研究者
Kari Anne Sveen
MD
Oslo University Hospital
研究点 (1)
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