Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 76
- 试验地点
- 1
- 主要终点
- Energy expenditure on activity monitor
研究概览
简要总结
The purpose of this study is to compare physical activity levels between patients with bronchiectasis and healthy subjects.
We hypothesize that patients with bronchiectasis will have lower levels of physical activity, since physical activity levels is affected by reduced exercise tolerance, severity of disease and other disease related symptoms and conditions.
详细描述
Physical activity limitation in chronic respiratory diseases is caused by many factors including respiratory, hemodynamic, and peripheral muscle weakness. Bronchiectasis is characterized by irreversible widening of the medium-sized airways, with inflammation, chronic bacterial infection and destruction of the bronchial walls. In addition to pulmonary function worsening, extra pulmonary features such as reduced peripheral muscle endurance can be a significant physical problem which causing a decrease in physical activity levels.
Despite physical activity is considered to be essential for the management of chronic respiratory diseases, there is a lack of scientific study, which compares physical activity levels between patients with bronchiectasis and healthy subjects.
This study will assess physical activity level, exercise capacity, quality of life and peripheral muscle strength in patients with bronchiectasis compared to healthy subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion criteria of the Bronchiectasis Group:
- •Diagnosis of bronchiectasis
- •Being 18 years of age or older
- •Able and willing to complete the informed consent process.
- •Able to walk and co-operate
排除标准
- •Exclusion criteria of Bronchiectasis Group:
- •Unstable medical condition
- •To have severe neurological, orthopedic problems or severe heart failure.
- •The control group will consist of healthy subjects.
结局指标
主要结局
Energy expenditure on activity monitor
时间窗: Seven days
Total energy expenditure will be calculated using activity monitor for seven consecutive days
Exercise capacity using 6-minute walk test and incremental shuttle walk test
时间窗: 8th day (after using device)
6-minute walk test will be performed in a long, straight, enclosed corridor 30 meters in length. Patients are required to walk in their walking speed with standardized instructions. The distance walked by subjects during 6 minutes will be recorded. The incremental shuttle walk test will be performed in an enclosed corridor. Patients are required to walk back and forth, turning around two cones placed 9 meters apart making the shuttle distance 10 meters long. Patients will follow the rhythm dictated by the audio signal.
Number of steps on accelerometer
时间窗: Seven days
Participants will wear an accelerometer (physical activity monitor) for seven consecutive days.
Physical activity level using International Physical Activity Questionnaire
时间窗: 8th day
Instrument to obtain internationally comparable data on health related physical activity This measure assesses the types of intensity of physical activity and sitting time in daily life and estimates total physical activity in MET-min/week and time spent sitting. It comprises open-ended questions surrounding individuals' last 7-day recall of physical activity.
次要结局
- Quality of Life using St. George Respiratory Questionnaire(1st day)
- Peripheral muscle strength test using a hand-held dynamometer(8th day (after using device))
- Shortness of breath using the Modified Medical Research Council Dyspnea Scale(1st day (before using device))
- Maximal inspiratory and expiratory pressures measurement using a mouthpiece device(8th day (after using device))
研究者
Aslihan CAKMAK
Research Assistant
Hacettepe University