A prospective, randomised, controlled trial to evaluate the efficacy and safety of endoscopic choroid plexus coagulation with third ventriculostomy in the treatment of idiopathic Normal Pressure Hydrocephalus

The Frenchay Hydrocephalus Research Fund (UK)0 个研究点目标入组 0 人开始时间: 2002年10月17日最近更新: 2016年10月17日

适应症

试验速览

暂无简介。

•1. A clinical diagnosis of Normal Pressure Hydrocephalus (NPH) by the following criteria:
•a. Evidence of significant gait disturbance in the absence of other causative factors
•b. Evidence of some cognitive impairment on formal neuropsychological testing (Mattis dementia rating scale and Folstein mini-mental state examination) and/or urinary incontinence or evidence of neurogenic urinary disturbance (frequency or urgency)
•c. Lumbar Opening Pressure less than 20 mmHg on supine lumbar puncture
•2. Symptom duration of more than six months
•3. Evidence of disease progression since onset of symptoms
•4. Radiological evidence of hydrocephalus, Evans ratio more than 0.3 on Computed Tomography (CT) scan of head
•5. Patients must be fit enough to undergo operative surgical treatment, as defined by an American Society of Anesthesiologists (ASA) score of one, two or three
•6. Written informed consent to participation in the study obtained from the patient, or next of kin if the patient is unable (due to cognitive impairment) to give informed consent

发起方

The Frenchay Hydrocephalus Research Fund (UK)