Thromboelastography During Surgery for Malignant Pleural Mesothelioma
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Coagulation profile during extrapleural pneumonectomy or pleurectomy
研究概览
简要总结
Surgery for malignant pleural mesothelioma is complex and prolonged, and may involve significant blood loss with considerable blood and product transfusion. Thromboelastography (TEG) is a global assay of coagulation that uses whole blood to produce a tracing that records kinetic changes in clot formation. This study aims provide a better understanding of the coagulation profile of these patients, and will form the basis of a TEG-based transfusion algorithm for future surgeries for mesothelioma.
详细描述
Thromboelastography can provide more in-depth and quicker analysis of the complex coagulation processes during surgery
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult male or female patients undergoing elective surgery for malignant pleural mesothelioma
排除标准
- •Unwilling or unable to provide consent
- •History of bleeding disorder
- •On medications that may affect hemostasis
结局指标
主要结局
Coagulation profile during extrapleural pneumonectomy or pleurectomy
时间窗: Surgical period (4-6 hours)
Reaction time, alpha angle, maximum amplitude and clot lysis from thromboelastography give a better picture of coagulation at different phases of surgery
次要结局
未报告次要终点
研究者
Ju-Mei Ng
Instructor of Anaesthesia
Brigham and Women's Hospital