Efficacy of Bupivacaine-magnesium Combination Versus Bupivacaine Alone in Genicular Nerve Block in Total Knee Replacement Surgeries: a Randomized Controlled Study
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- Numerical Rating Scale
研究概览
简要总结
It is proved that the addition of magnesium sulfate to local anesthetics for neuraxial anesthesia improves the quality of analgesia and prolongs the duration of anesthesia . In-vitro and in-vivo studies have demonstrated that magnesium enhances the local anesthetics effect on peripheral nerves .
No previous studies were conducted on magnesium sulfate as an adjuvant to the local anesthetic in genicular nerve block. Hence, this study will be conducted to assess analgesic efficacy of magnesium sulfate when added to bupivacaine in ultrasound guided genicular nerve block
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologist (ASA) I or II physical status.
- •Between 18 and 70 years of age.
- •Both genders.
- •Patients undergoing total knee replacement surgery.
排除标准
- •Patient refusal.
- •ASA Ⅲ and Ⅳ patients.
- •Known allergy to the study drugs.
- •Hypermagnesemia.
- •Central or peripheral neurological disease.
- •Pregnancy.
- •Drug or alcohol abuse.
- •Localized infection at the site of the block.
- •Bleeding disorder (platelets count less than 100,000 or international normalized ratio more than 1.4)
结局指标
主要结局
Numerical Rating Scale
时间窗: 24 hours post-operatively
Pain will be assessed with Numerical Rating Scale. Patients will be asked to circle the number between 0 and 10, that fits best to their pain intensity. Zero usually represents 'no pain at all' whereas the upper limit represents 'the worst pain ever possible.
次要结局
- Patient satisfaction(24 hours post-operatively)
- First request for analgesia(24 hours post-operatively)
- Total opioid consumption(24 hours post-operatively)
研究者
AbdElKhalik Mahmoud Shaban
Lecturer of anaesthesia
Cairo University