Evaluation of Extra pharmacopeial herb Bhangjeera (Perilla frutescens Linn.) seed in the management of Generalized Anxiety Disorder (GAD) in adults: An Exploratory Clinical Study

Anxiety disorders (ADs) are among the most common psychiatric illnesses that impact the quality of life, functioning and productivity of an individual. As per the World Mental Health Survey (WMHS), the lifetime prevalence of Anxiety disorders across different countries ranges between 3% and 19%. According to NMHS 2016, prevalence of ADs was 2.57%.Though, the prevalence of anxiety disorder is less but the overall quality of life of these patients is poor. The conventional treatment of this condition indicates the use of sedatives, hypnotics and antidepressant drugs along with the cognitive behavioral therapy. Still, the prognosis for patients with generalized anxiety disorder is guarded. Many patients are not compliant with medications because of cost and adverse effects. Relapses are common, and patients often search for physicians who comply with their needs. Because of the lack of conventional medicine to cure the disorder and their considerable side effects, many opt for alternative therapies.The herb Bhangjeera (Perilla frutescens Linn) has traditionally been used to treat depression-related disease, and is reported as potent anxiolytic. Japan has reported its clinical potential in Age related Cognitive Decline (ARCD).  Reviews reflect that oral administration of seed is not reported in any clinical studies. Due to unfavorable palatability of seeds in their original form, it is difficult to administer the seeds for therapeutic purposes for longer duration. To explore its utilization, efforts are needed for development of better consumable forms / food products, so that they can be incorporated in the diets of common man. Further the developed consumable forms can also be used to ensure better patient compliance and evaluation of herb for its pharmacological potential.