Expert Consensus on the Use of Isotretinoin in Rejuvenation: A Delphi Study
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Primary Outcome
研究概览
简要总结
This expert consensus project explores the role of low-dose isotretinoin as a rejuvenative and preventive strategy for photoaging and sebaceous-driven skin changes. While isotretinoin is traditionally used for acne, increasing clinical experience suggests that carefully selected micro-dose and low-dose regimens may improve skin texture, pore size, sebaceous activity, and overall skin quality, with potential benefits in skin aging and maintenance rejuvenation programs.
详细描述
This study is a non-interventional, Delphi-based expert consensus project designed to establish recommendations for the use of isotretinoin in skin rejuvenation. While isotretinoin is primarily indicated for acne, accumulating clinical evidence and practitioner experience suggest that low-dose or micro-dose regimens may contribute to improvements in skin texture, fine lines, pore size, sebaceous activity, and overall skin quality. However, standardized guidance on indications, dosing, treatment duration, monitoring, and safety precautions is limited.
A panel of expert dermatologists with practical experience in isotretinoin therapy and skin rejuvenation will be invited to participate in multiple iterative Delphi rounds. Experts will rate agreement with proposed statements using a structured Likert scale. After each round, anonymized feedback will be provided, and statements not reaching consensus will be revised and re-evaluated until stable agreement is achieved.
The final output will consist of consensus-based recommendations reflecting practical, safe, and evidence-informed guidance for dermatologists considering isotretinoin for rejuvenation purposes. The study will also identify areas of uncertainty where further research is needed, supporting the safe expansion of isotretinoin applications beyond acne management.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Board-certified dermatologists or equivalent.
- •5 years clinical experience in dermatology.
- •Practical experience prescribing isotretinoin, including low- or micro-dose regimens for rejuvenation or acne.
- •Active engagement in clinical dermatology, teaching, research, or guideline development.
- •Willingness to participate in all Delphi rounds and provide informed consent.
排除标准
- •Non-dermatology specialists.
- •Less than 5 years of clinical experience.
- •Lack of relevant isotretinoin experience.
- •Significant undisclosed conflict of interest with isotretinoin manufacturers.
- •Inability to participate in all Delphi rounds.
结局指标
主要结局
Primary Outcome
时间窗: 6-12 weeks
Level of expert consensus on statements regarding the use of isotretinoin for skin rejuvenation, measured as the proportion of panelists reaching a predefined agreement threshold (e.g., ≥70-80%) per statement.
次要结局
- Secondary Outcome(6-12 weeks)