Effect of Surgical Periodontal Therapy on the RANKL/OPG System : Do we Need Osteo-immune Modulation Targeting RANKL?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- OPG level (pg) in GCF
研究概览
简要总结
In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Chronic periodontitis having at least 5mm or more probing depth and aggressive periodontitis patients.
排除标准
- •Any known systemic disorder, used antibiotics and/or anti-inflammatory medications, had periodontal treatment in the last 3 months and all of them were non smokers. Subjects who were lactating and pregnant were also excluded.
结局指标
主要结局
OPG level (pg) in GCF
时间窗: Baseline-3 months
Changes in OPG levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
RANKL (pmol) level in GCF
时间窗: Baseline-3 months
Changes in RANKL levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
RANKL/OPG ratio
时间窗: Baseline - 3months
RANKL/OPG ratio changes 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis
次要结局
- IL-1β (pg) levels in GCF(Baseline, 3 months after treatment)
- Il-10 (pg) levels in GCF(Baseline-3 months)
研究者
Ezel Berker
Ezel Berker
Hacettepe University