Identification Sepsis Related SNP by Whole Exome Sequencing: a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- sepsis related SNP site
研究概览
简要总结
Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. Single nucleotide polymorphism (SNP) was promising genetic biomarker for sepsis patients. The present study was designed to screen several SNP by whole exome sequencing which evaluate the sepsis related snp site in order to be a new target for the treatment of sepsis.
详细描述
The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several SNPs by whole exome sequencing which can be used as genetic marker for sepsis patients. We will collect whole blood samples from patients with sepsis inRespiratory Intensive Care Unit (RICU), the Emergency Intensive Care Unit (EICU), or the Department of Surgery's ICU 301 Hospital since January 2013, and then whole exome sequencing was used to Screen SNPs which were related to sepsis. Then another 500 sepsis patients and 500 normal controls were used to validated the sequencing results.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of sepsis
- •Patients who agree with the study
排除标准
- •Aged <18 years;
- •Into the group who died within 24 hours;
- •Agranulocytosis (<0.5 × 109 / L);
- •Combined HIV infection.
结局指标
主要结局
sepsis related SNP site
时间窗: 28 days after admitted to ICU
次要结局
未报告次要终点
研究者
Huijuan Wang
Dr
Chinese PLA General Hospital