A Virtual Clinical Trial to Assess the Impact of Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Dose Difference in 99% Planning Target Volume (PTV) Coverage Between Single Energy CT and Dual Energy CT
研究概览
简要总结
The aim of this protocol is to refine the accuracy of proton beam therapy (PT) by the use of dual energy computed tomography (DECT), in conjunction with novel iterative image reconstruction algorithms, to more precisely determine the tissue properties through which the proton beam path travels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of histologically proven primary or metastatic cancer requiring thoracic radiation therapy OR radiation therapy to the head and neck or brain
- •At least 18 years of age.
- •Planning to undergo proton or photon beam radiation therapy as part of the clinical management of the diagnosed cancer.
- •Able to understand and willing to sign an IRB-approved written informed consent document.
排除标准
- •Implanted metallic objects in the region to be scanned excepting dental prostheses
- •IV or oral contrast medium within 24 hours prior to DECT image acqusition
- •Pregnant.
研究组 & 干预措施
Dual-Energy CT scan
Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.
干预措施: Siemens Somatom Definition Edge (Device)
Dual-Energy CT scan
Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.
干预措施: Philips Brilliance Big Bore CT/simulator (Device)
结局指标
主要结局
Dose Difference in 99% Planning Target Volume (PTV) Coverage Between Single Energy CT and Dual Energy CT
时间窗: Day 1
次要结局
未报告次要终点