Glycocalyx as Predictor of Complications After Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- association between preoperative sublingual glycocalyx thickness (glycocheck device) and major postoperative complications
研究概览
简要总结
Cardiac surgery has been described as altering endothelium structure and function, notably because of the use of cardiac-pulmonary bypass (CPB). Among the endothelial structure, glycocalyx, the thin layer recovering the endothelial surface, may be altered by the inflammatory process and probably the modification of flow during CPB. Endothelial and glycocalyx integrity are essential for vascular function and glycocalyx destruction is associated with organ failure and mortality. On the other hand, a chronic alteration of glycocalyx is observed in many diseases such as diabetes, hypertension or chronic kidney failure, all pathologies frequently observed in patients benefiting grom cardiac surgery.
Thus the preoperative alteration of glycocalyx may be associated with postoperative organ failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients benefiting from a cardiac surgery with cardio-pulmonary bypass
排除标准
- •impossibility to carry out the measurement by glycocheck device
- •refusal to participate
结局指标
主要结局
association between preoperative sublingual glycocalyx thickness (glycocheck device) and major postoperative complications
时间窗: 48 hours
occurence within 48 postoperative hours of at least one item among: * vasoplegic shock * cardiogenic shock * prolonged mechanical ventilation * acute kidney failure * Death
次要结局
- association between preoperative sublingual glycocalyx thickness (glycocheck device) and myocardial ischemia(28 days)
- association between preoperative sublingual glycocalyx thickness (glycocheck device) and acute respiratory failure(28 days)
- association between preoperative sublingual glycocalyx thickness (glycocheck device) and sepsis(28 days)
- association between preoperative sublingual glycocalyx thickness (glycocheck device) and death(28 days)
- association between preoperative sublingual glycocalyx thickness (glycocheck device) and cardiac arrythmia(28 days)
- association between preoperative sublingual glycocalyx thickness (glycocheck device) and Cerebral stroke(28 days)
- association between preoperative sublingual glycocalyx thickness (glycocheck device) and cognitive dysfunction(28 days)