Brain Activity Assessment by Functional MRI Before, After Radiofrequency of Gasserian Ganglia in Patient With Trigeminal Neuralgia
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- pain alleviation
研究概览
简要总结
To investigate the brain activations related to TN, using fMRI, and to evaluate changes in these activations following the application of pulsed and thermal Radiofrequency lesioning to the gasserien ganglion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 20 - 65 years
- •Primary trigeminal neuralgia
- •Maxillary and/or mandibular affection only
- •Failure of medical treatment
排除标准
- •2ry trigeminal neuralgia
- •Recurrent trigeminal neuralgia
- •Ophthalmic branch affection
- •Contraindication for intervention (sepsis, coagulopathy, infection at entery point, local anesthetic allergy,...)
- •Pregnancy
研究组 & 干预措施
pulsed radiofrequency
sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then pulsed radiofrequency will be applied for 10 patients for 10 mins
干预措施: pulsed Radiofrequency (Procedure)
thermal Radiofrequency
sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then Thermal lesion will be applied for 10 patients for 2 cycles of 90 seconds
干预措施: thermal Radiofrequency (Procedure)
结局指标
主要结局
pain alleviation
时间窗: 1 month
pain assessment by functional MRI
次要结局
未报告次要终点
研究者
mohamed elsayed
assisstant lecture
Assiut University