Fluoride PET-CT imaging for the detection of bone formation in (very) early and preclinical spondyloarthritis

Amsterdam UMC0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•In order to be eligible to participate in this study, a subject must meet all of the following criteria of the original Pre-Spa cohort:
•- First-degree relatives of HLA-B27 positive AxSpA patients
•- Age between 18 and 40 years at time of inclusion
•- Able and willing to give written informed consent .
•For this specific pilot project, we include:
•- 10 participants with an MRI highly suggestive of SpA according to the
•ASAS definition at baseline
•- 10 participants without an MRI suggestive of SpA according to the ASAS
•definition at baseline.

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•- Patients already diagnosed with spondyloarthritis
•- Individuals with concomitant conditions which may impact participation to the study or interpretation of the data, such as
•- Individuals that have an arthritic disease other than SpA
•- Individuals that have a diagnosed condition with back pain other than SpA (example: diagnosed intervertebral disc degeneration)
•- Individuals with communication problems
•- Individuals with psychiatric diseases
•- Individuals with drug abuse
•- Individuals with a life expectancy of less than five years
•- Individuals who are pregnant or have a positive hcg urine test
•- Individuals who are breastfeeding
•- Individuals who have received treatment with any investigational drug within previous 3 months
•- Individuals who already received a research related radiation burden (cumulative > 5 mSy) in the year before inclusion
•- Other conditions by judgement of the physician

发起方

Amsterdam UMC