NCT01344330已完成不适用
Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- Cruciferous vegetable intake correlated with SFN and I3C urinary metabolites
研究概览
简要总结
This research study will assess cruciferous vegetable intake in patients presenting for screening colonoscopy and correlate intake with histone status and histone deacetylace (HDAC) expression in tissue biopsy specimens and peripheral blood mononuclear cells (PBMCs). The investigators will also measure sulforaphane (SFN) metabolites in blood as a biomarker of cruciferous vegetable intake.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Cruciferous vegetable intake correlated with SFN and I3C urinary metabolites
时间窗: At colonoscopy (day 1)
次要结局
- Cruciferous vegetable intake and p21 expression (qRT-PCR, ChIP in PBMCs)(at colonoscopy)
- Cruciferous vegetable intake correlated with acetylated histone expression (PBMCs, colon tissue),(at colonoscopy)
- Cruciferous vegetable intake correlated with HDAC activity (in PBMCs)(at colonoscopy)
研究者
Roderick Dashwood
Professor, Texas A&M HSC
Texas A&M University
研究点 (1)
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