Multi-centred Clinico-genetic Study of Actinic Prurigo in Thailand
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 47
- 试验地点
- 2
- 主要终点
- Targeted long-read HLA sequencing
研究概览
简要总结
This research project investigates the clinical and genetic associations of Actinic Prurigo (AP) in the Thai population. As a rare chronic photodermatosis, AP has been observed to occur more frequently in individuals with certain genetic predispositions, particularly specific Human Leukocyte Antigen (HLA) types. Previous studies have suggested variations in clinical presentation and HLA allele distributions between Asian and Western populations.
The primary aim is to explore the relationship between clinical manifestations of AP and genetic profiles, including HLA typing, among Thai individuals. Additionally, the study seeks to examine whether different HLA types are associated with varying responses to treatment.
The study design is a cross-sectional comparative study, involving both AP patients and age-matched healthy controls. Given the rarity of the condition, patient recruitment will be conducted across four collaborating institutions:
King Chulalongkorn Memorial Hospital Siriraj Hospital Institute of Dermatology
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Thai ethnicity
- •Diagnosed with Actinic Prurigo (AP) according to the diagnostic criteria defined for this study
- •Mentally competent, able to communicate, and able to read Thai.
- •Participants receiving Thalidomide treatment must use two simultaneous methods of contraception, starting at least 4 weeks prior to initiating the medication and continuing throughout the treatment period and for at least 4 weeks after discontinuation.
排除标准
- •History and physical examination findings suggestive of other photodermatoses such as Lupus erythematosus, Porphyria, or Polymorphous Light Eruption, among others.
- •Elevated Epstein-Barr Virus (EBV) viral load detected in blood testing (EBV viral load will be tested in all participants).
- •Low Minimal Erythema Dose (MED) to UVB radiation as the only abnormal finding.
结局指标
主要结局
Targeted long-read HLA sequencing
时间窗: through study completion, an average of 1 year
Correlation between the occurrence of Actinic Prurigo (AP), its clinical manifestations, and genetic factors-including HLA types-in individuals of Thai ancestry.
Targeted long-read HLA sequencing
时间窗: through study completion, an average of 1 year
Correlation between the occurrence of Actinic Prurigo (AP), its clinical manifestations, and genetic factors-including HLA types-in individuals of Thai ancestry.
次要结局
- Immunology study(through study completion, an average of 1 year)
- Short-read whole genome sequencing (WGS)(through study completion, an average of 1 year)
- Short-read whole genome sequencing (WGS)(through study completion, an average of 1 year)
- Immunology study(through study completion, an average of 1 year)
研究者
Einapak Boontaveeyuwat, MD
Asst. Prof
Chulalongkorn University