Role of MAGNETIC RESONANCE IMAGING in Characterization of Superficial Soft Tissue Masses
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 主要终点
- benign and malignant masses
研究概览
简要总结
This study responds to these raise up questions: Can we use Diffusion Weighted MR complemented with numerical ADC values & in association with routine MRI in the discrimination between different malignant and benign superficial soft tissue masses.
详细描述
In the clinical practice, there is a large number & variety of superficial soft tissue masses. The differentiation of such masses represents a major obstacle for the surgeons. Benign &malignant neoplasms as well as non-neoplastic swellings may have similar clinical presentation. The differentiation between malignant & benign superficial soft tissue neoplasms is required for appropriate therapeutic planning and decisions. Masses can be characterized in terms of their size, number, component &vascularity using US and Doppler US. However, US is operator dependent & may display a number of artifacts that can result in misinterpretation. So MRI is superior in the assessment of such soft tissue masses due its brilliant soft tissue discrimination. Some features that will help distinguish malignant from benign lesions are evident on MRI examination such as signal characteristics,enhancement pattern,margin,lobulation,necrosis, haemorrhage,internal septation,peritumoral edema and extension through the deep fascia .However very forcful tumors may show benign behavior & appear similar to benign masses , Thus further histopathology is required for accurate diagnosis. Diffusion weighted MRI visualizes the random microscopic motion of molecules. Diffusion-weighted imaging (DWI) is the technique which allows measurement of the Brownian motion of water in the tissue microenvironment depending on the organization of the tissue, integrity of cell membranes, and tortuosity of extracellular space. Apparent Diffusion Coefficient (ADC) is a numerical parameter which is calculated from DWI. Previously, DWI technique was used with great success in the central nervous system (CNS), in the differentiation between benign and malignant tumors in addition to its great value in early diagnosis of recent strokes. Nowadays, DWI was used in the differentiation between malignant and benign soft tissue masses. Malignant tumors have abundant cellularity than benign tumors hence they have more restricted diffusion. The addition of quantitative ADC values plays a fundamental role in more accurate diagnosis of malignant superficial soft tissue neoplasms.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with superficial soft tissue masses clinically
- •patients underwent us detection of superficial soft tissue masses
- •uncharactized superficial soft tissue mass by other modalities
排除标准
- •MRI claustrophobia
- •recurrent cases
- •patients under treatment
结局指标
主要结局
benign and malignant masses
时间窗: from october 2021 to october2022
The discrimination between benign and malignant superficial soft tissue mass by Non invasive available technique
次要结局
- Type of malignant superficial soft tissue masses(From October 2021 to October 2022)
研究者
Fatma Alzahraa Mohamed Hassan Anwar
resident
Assiut University
