The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Change in forearm blood flow in response to vasodilators (ACh) and ischaemia reperfusion
研究概览
简要总结
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed to relieve this blockage as quickly as possible to minimize damage to the heart muscle. However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help the investigators to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy males between 18-65 years of ages
- •non-smokers
排除标准
- •any concurrent illness or chronic medical condition
- •concurrent use of vasoactive medication
- •smoking history
研究组 & 干预措施
1
Ischaemia 20 minutes. Blood pressure cuff will be inflated to 200mmHg around the upper arm for 20 minutes to induce ischaemia. Systemic infusion of placebo (saline).
干预措施: Forearm vascular study (Procedure)
1
Ischaemia 20 minutes. Blood pressure cuff will be inflated to 200mmHg around the upper arm for 20 minutes to induce ischaemia. Systemic infusion of placebo (saline).
干预措施: Placebo (saline) (Drug)
2
Ischaemia 20 minutes. Blood pressure cuff will be inflated to 200mmHg around the upper arm for 20 minutes to induce ischaemia. Systemic infusion of bradykinin receptor antagonist (HOE-140).
干预措施: Forearm vascular study (Procedure)
2
Ischaemia 20 minutes. Blood pressure cuff will be inflated to 200mmHg around the upper arm for 20 minutes to induce ischaemia. Systemic infusion of bradykinin receptor antagonist (HOE-140).
干预措施: bradykinin receptor antagonist (HOE-140) (Drug)
结局指标
主要结局
Change in forearm blood flow in response to vasodilators (ACh) and ischaemia reperfusion
时间窗: 20 fixed timepoints during each study visit (3hrs)
次要结局
- Change in platelet-monocyte-binding after ischaemia reperfusion(4 fixed timepoints during each study visit (3hrs))