Evaluation of efficacy of nebulised dexmedetomidine in attenuation of haemodynamic response to laryngoscopy and intubation.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Study is to evaluate the two groups in order to assess the following
研究概览
简要总结
To evaluate the effect of nebulised dexmedetomidine in attenuation of haemodynamic response to laryngoscopy and intubation.Nebulised dexmedetomidine will be given at dosage of 1mcg/kg that is to be mixed with the saline to a total volume of 5 ml and the nebulisation will be given with the nebulisation mask for period of 10 min in sitting position before induction of anesthesia .Injection of midazolam 30 mcg/kg ,injection Glycopyrollate 20 mcg/kg,and Nalbuphine 0.1mg/kg will be given to premedicate the patient .Patient will also be pre oxygenated for 3 minutes and propofol at a dose of 2 mg/kg will be given to induce the patient and patient will be monitored for doseage amounts until verbal response is lost and given vecuronium at dose 0.1mg/kg as a muscle relaxant to help in the intubation.Consultant anaesthesiologist will do Direct laryngyoscopy with appropriate size Macintosh blade and intubate the patient using appropriate size endotracheal tube and link It to the ventilator 10 minutes after intubation ,
the critical indicators such as THE HEART RATE ,THE BLOOD PRESSURE{ SYSTOLIC BLOOD PRESSURE,DIASTOLIC PRESSURE,MEAN ARTERIAL PRESSURE)will be noted via the baseline vitals.Post nebulisation and post intubation at 1 minute,5 minute ,10 minute by an anesthesia resident who is not currently participating in the project.Diclofenac 75 mg injection will be given intraopertively to all patients.After surgery the neuromuscular blockade will be removed by injection glycopyrollate and neostigmine and then patient will be extubated if they have met the extubation requirement and they will then be send to the post anesthsia care unit.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •o American Society of Anaesthesiologists class 1 and 2 patients.
- •o Mallampati Grading I and II.
- •o Undergoing elective surgery under general anaesthesia and endotracheal intubation needed.
- •o Patient between age 18 to 60 years.
排除标准
- •o American Society of Anaesthesiologists class III and IV.
- •o Patient not consenting for the study.
- •o Predicted difficulty airway.
- •o Known allergy to dexmedetomidine o Patient on B-blockers o Pregnant females.
- •o Kidney failure o Uncontrolled hypertensive patient o Seizure disorders.
- •o Patient taking medications such as anti-depressants or anti-psychotics.
- •o Patients with decrease cardiac output.
- •o Obese patient with Body mass index of more than 30 kg/metre square.
结局指标
主要结局
Study is to evaluate the two groups in order to assess the following
时间窗: Heart rate , the blood | pressure (systolic , diastolic and the mean arterial pressure will be noted by the baseline vitals, the post-nebulization (post-neb), and the post-intubation at 1, 5, and 10 minutes will be noted.
VITALS: heart rate, systolic and diastolic blood pressure, mean arterial pressure.
时间窗: Heart rate , the blood | pressure (systolic , diastolic and the mean arterial pressure will be noted by the baseline vitals, the post-nebulization (post-neb), and the post-intubation at 1, 5, and 10 minutes will be noted.
次要结局
- To study any adverse effect of drug such as bradycardia,, hypotension, coughing and sore throat.(In postoperative ward after extubation.)
研究者
Dr Tarandeep Singh Bajwa
Maharishi markandeshwar medical college and hospital