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临床试验/NCT07692659
NCT07692659尚未招募不适用

Comparison of Ultrasound Guided Bilateral Parasternal Block With Bilateral Rectus Sheath Block Versus Ultrasound Guided Bilateral Erector Spinae Plane Block in Controlling Intra and Post-operative Pain After Cardiac Surgeries

National Cancer Institute, Egypt0 个研究点目标入组 50 人开始时间: 2026年7月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
50
主要终点
Numeric rating score

研究概览

简要总结

The researchers are working to improve recovery after heart surgery by reducing reliance on opioids. Newer regional anesthesia techniques can provide strong pain relief with fewer risks, but the choice of method depends on each patient's condition, medications, and surgical plan

详细描述

Optimal anesthesia in cardiac surgery requires careful management to avoid sympathetic stimulation, with analgesia being central to patient safety and recovery. Traditionally, high-dose opioids were used, but this approach delays extubation, conflicting with fast-track protocols that emphasize early extubation. Consequently, opioid-free analgesia has gained importance, employing regional techniques such as neuraxial, paravertebral, and fascial plane blocks.

Thoracic epidural analgesia (TEA) offers effective pain control and reduces perioperative cardiovascular and respiratory complications. However, its use in anticoagulated patients raises concern for epidural hematoma. Alternatives like paravertebral and fascial plane blocks provide comparable analgesia with lower risk. The erector spinae plane block (ESPB) reduces analgesic requirements, though deep blocks still pose bleeding risks.

Superficial plane blocks are therefore clinically valuable. The parasternal intercostal block-targeting anterior cutaneous branches of intercostal nerves-has emerged as a safe option for patients undergoing median sternotomy while on anticoagulant or antiplatelet therapy. Additionally, bilateral rectus sheath block can reduce chest tube insertion pain after cardiac surgery.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Both sexes,
  • ASA III-IV patients
  • body mass index between 20- 35 kg/m2
  • adult patients above 18 years old will be included in the study

排除标准

  • Patients with global hypokinesia
  • ejection fraction < 40%
  • low platelet count
  • coagulation impairment
  • deformity in the vertebral column
  • severe renal and hepatic impairment
  • any known allergy to the drugs used

研究组 & 干预措施

Parasternal/ Rectus sheath

Experimental

Patients will receive Parasternal and rectus sheath blocks; with injection of 10 ml bupivacaine 0.25% in each side after confirmation of needle position. Both parasternal and rectus heath blocks will be performed bilaterally

干预措施: Parasternal/ Rectus sheath block (Procedure)

Erector Spinae Plane Block

Experimental

The patients will receive a bilateral ESPB with an injection of 20 ml of bupivacaine 0.25%.

干预措施: Erector spinae plane block (Procedure)

结局指标

主要结局

Numeric rating score

时间窗: 24 hours

postoperative pain scores using Numerical Rating Scale (NRS) with 0 meaning no pain and 10 meaning the worst pain level

次要结局

  • postoperative opioid consumption(24 hours)
  • extubation time(immediate postoperative)
  • first time to request analgesia(24 hours)
  • peri-operative hemodynamics(intraoperative and 24 hours)

研究者

发起方
National Cancer Institute, Egypt
申办方类型
Other
责任方
Principal Investigator
主要研究者

Walaa Youssef Elsabeeny

Assistant professor of Anesthesia, Surgical Critical Care and Pain management

National Cancer Institute, Egypt

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