A Cross-Sectional study on Rasavaha Srotodushti Lakshana in primary Hypothyroidism and evaluating the therapeutic efficacy of Kanchanar Guggulu with Rasapachak Kwatha versus Kanchanara Triphala Kwatha on Thyroid function.

Hypothyroidism is the most common endocrine disorder that affects a significant portion of the global population. The prevalence of hypothyroidism in urban India is 10.95% with a greater incidence in females and elderly persons. The thyroid gland produces two hormones, Thyroxine (T4) and Triiodothyronine (T3). The deficiency of thyroid hormone is a common condition worldwide. It affects almost all body systems and has a wide variety of clinical presentations from being asymptomatic to, in rare cases, life threatening. Ayurveda does not currently have a description of any disease condition comparable to hypothyroidism. Yet, several references are scattered in various texts. Understanding of hypothyroidism as per Ayurvedic science suggests Kapha and Meda derangements, With the involvement of Kapha, Vata dosha, along with the Srotas involved are Rasavaha, Mamsavaha, Medovaha, Purishavaha, Annavaha, Pranavaha, Manovaha, and Arthavavaha.

NEED OF THE STUDY: On the basis of clinical manifestation and etiological factors of hypothyroidism it may be considered primarily caused due to Derangement of Agni, Rasavaha Srotas and Medovaha Srotas as per ayurveda perspective.

Some previous studies have documented the role of Rasavaha Sroto dushti in hypothyroidism, however, to the best knowledge of the authors, none of the previous studies have used validated performa (Questionnaire) for the same, which reduces their scientific credibility. This study may provide a deeper understanding of the disease’s pathophysiology from an Ayurvedic perspective. It also helps in identifying which symptoms are most prevalent or severe in this specific population, guiding the development of more targeted interventions.

This study also plans for further confirmation of association between Rasavaha srotodushti lakshanas and hypothyroidism through the usage of Rasapachak Kwatha, which acts mainly on Rasa Dhatu. If the Rasapachak Kwatha can mitigate the symptoms of hypothyroidism it may uphold the association of Rasavaha Srotodushti lakshanas in hypothyroidism. Additionally, it may also demonstrate how Ayurvedic treatments can more effectively balance the disturbances in Rasavaha Srotas and provide a holistic approach to managing hypothyroidism. AIM:

Examine the relationship between Rasavaha Srotodushti symptoms and hypothyroidism by comparing the therapeutic effects of Rasapachak Kwatha combined with Kanchanar Guggulu versus Kanchnara Triphala Kwatha combined with Kanchanar Guggulu, based on various subjective and objective parameters.

OBJECTIVE:

Primary Objective:

1)    To assess the therapeutic effects of Rasapachak Kwatha combined with Kanchanar Guggulu versus Kanchnara Triphala Kwatha combined with Kanchnar Guggulu on hypothyroidism, based on thyroid function (TSH).

Secondary Objective:

1)    To compare their impact on T3, T4, and clinical symptoms of hypothyroidism