Electroencephalographic Patterns of Septic Patients and Its Correlation With Cognitive Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Electroencephalographic patterns
研究概览
简要总结
The investigators evaluated the electroencephalographic pattern by the Sinek and Young scales during ICU stay and its correlation with cognitive impairment determined by the Montreal Cognitive Assessment (MOCA) in septic patients after 3 months of ICU discharge..
详细描述
The investigators prospectively evaluate patients with sepsis and septic shock expected to stay in the intensive care unit (ICU) for at least 4 days. We used Sinek and Young scales to classify electroencephalographic patterns during ICU stay (in the first 24 hours after admission and in the third ICU day) and correlate with cognitive outcome evaluated with MOCA score 3 months after ICU discharge. The investigators evaluate as primary outcome the association between electroencephalographic abnormalities and cognitive dysfunction measured by the Montreal Cognitive Assessment (MoCA) 3 months after ICU discharge and secondary outcomes as association between electroencephalographic patterns and 28 days mortality, Quality of Life (SF-36) after 3 months of discharge, ventilator free days, vasoactive drug free days and Glasgow outcome scale.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Included were patients aged above 18 years, who were expected to stay in the ICU for at least 4 days, between November 2021 and November
排除标准
- •CNS infections,
- •Structural abnormalities of the CNS, known
- •Liver or uremic encephalopathy,
- •Advanced dementia (Mini mental < 9),
- •Psychiatric disorder
- •Epilepsy.
结局指标
主要结局
Electroencephalographic patterns
时间窗: 3 months after hospital discharge
Electroencephalographic patterns determined by Sinek and Young scales. The Synek outcome Scale ranges from normal (alpha dominant rhythm) to suppression (worst outcome). The scale assesses the outcome of patients with sepsis. Young's Scale Electroencephalographic classification of coma assesses outcome of patients with sepsis Outcome varies from normal (Delta/Theta Rhythm \> 50% of record). worst result Suppression The two scales are complementary.
Cognitive evaluation
时间窗: 3 months after hospital discharge
Cognitive dysfunction measured by Montreal Cognitive Assessment (MoCA)
次要结局
- electroencephalographic patterns and 28 days mortality .(28 days)
- Quality of Life (SF-36) after 3 months of discharge(3 months after hospital discharge)
研究者
José Raimundo Araujo de Azevedo
ICU Coordinator
Hospital Sao Domingos