Early Indicators for Obstructive Airway Complications After Lung
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Primary endpoint of this study was any obstructive airway complication (AC) which required desobliterative intervention.
研究概览
简要总结
Airway complications are a significant cause of morbidity after lung transplantation (LTx). Bronchoscopic evaluation may help to identify risk factors for requiring interventions later.
详细描述
The investigators evaluated lung transplant recipients prospectively. Adult patients surviving 90 day after LTx will be included. The investigators propose a classification of airway healing based on the endoscopic bronchial appearances at days 7, 14, 21, 90, 180 and 365 after LTx. A score system including mucosal healing, full tissue necrosis (=dehiscence), lose sutures, fibrin plugs, polyps and malacia will be developed (max. score 8 points/date). Endoscopic findings will be correlated with the development of obstructive airway complications (OAC, requiring >1 intervention). Afterwards the new score system will be applied prospectively in the patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •3 month survivor after LTx
排除标准
- 未提供
结局指标
主要结局
Primary endpoint of this study was any obstructive airway complication (AC) which required desobliterative intervention.
时间窗: 1 year
次要结局
- secondary endpoint included anastomosis-related death.(1 year)
研究者
Thomas Fuehner
Principal Investigator
Hannover Medical School