Investigation of the Effect of Toothpastes With Different Ingredients on Oral Malodor in Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Change in oral malodor severity
研究概览
简要总结
This study aimed to evaluate the effects of different toothpaste formulations on oral malodor in young adults, addressing the lack of clinical evidence regarding propolis- and probiotic-containing toothpastes, which have predominantly been investigated in mouthrinse, tablet, or chewing gum formulations.
Volunteers aged 18-30 years with baseline organoleptic assessment (OA) and Breath Checker® (BC) scores >0 were randomized into four toothpaste groups: propolis-containing (Glimo Beta), probiotic-containing (Glimo Pi), phosphate-based (Glimo Gamma), and a standard fluoride toothpaste (Sensodyne). Allocation concealment was ensured using identical coded containers, and outcome assessors were blinded. After exclusions, 52 participants completed the study. Oral malodor was evaluated at baseline (T0) and Day 14 (T1) using OA, BC measurements, and self-perceived oral malodor scores.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •• No systemic diseases or medications known to cause halitosis
- •No active periodontal disease requiring treatment
- •No antibiotic use within the previous month
- •No orthodontic or removable space-maintaining appliances
- •Non-smokers
- •Organoleptic score >0 and Breath-Checker® (BC) score >0 at baseline
排除标准
- •Participants reporting systemic conditions, active periodontal therapy, smoking, or antibiotic usage were excluded.
研究组 & 干预措施
Propolis containing toothpaste
Participants in this arm used propolis containing toothpaste twice daily for routine oral hygiene during the study period.
干预措施: Propolis Containing Toothpaste (Other)
probiotic containing toothpaste
Participants in this arm used probiotic containing toothpaste twice daily for routine oral hygiene during the study period.
干预措施: Probiotic containing toothpaste (Other)
Phosphate-based formulation toothpaste
Participants in this arm used phosphate-based formulation toothpaste twice daily for routine oral hygiene during the study period.
干预措施: Phosphate-based formulation toothpaste (Other)
Standard fluoride
Participants in this arm used standard fluoride containing toothpaste twice daily for routine oral hygiene during the study period.
干预措施: Standard fluoride toothpaste (Other)
结局指标
主要结局
Change in oral malodor severity
时间窗: Baseline and Day 14
Oral malodor was assessed using an organoleptic scoring method and a portable breath checker device. The change in scores from baseline to the end of the intervention period was evaluated.
次要结局
未报告次要终点
研究者
Basak Karasu
Assisstant Professor
Çankırı Karatekin University